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Dispose of properly : Discard the used butterfly into an approved sharps container

Animal models frequently employ single high doses or repeated supraphysiological doses (e.g., 100200 mg/kg, i.p.) to induce rapid ovarian failure, while human chemotherapy protocols typically involve lower fractionated doses administered over longer periods

However, the effect varies, is not guaranteed, and the evidence is still limited

Although the differences in antibodies against Klotho isoforms may partially account for the discrepant findings ( Consequently, due to the above contradictions and insufficient data, the association of sKlotho with VC remains uncertain and needs to be clarified in the future